Magnesium in PDB 6uir: Hiv-1 M184V Reverse Transcriptase-Dna Complex with (-)-Ftc-Tp

All present enzymatic activity of Hiv-1 M184V Reverse Transcriptase-Dna Complex with (-)-Ftc-Tp:
2.7.7.49; 2.7.7.7; 3.1.26.13;

The structure of Hiv-1 M184V Reverse Transcriptase-Dna Complex with (-)-Ftc-Tp, PDB code: 6uir was solved by E.B.Lansdon, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	47.62 / 2.64
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	165.867, 170.112, 103.372, 90.00, 90.00, 90.00
R / Rfree (%)	19.6 / 26.4

The structure of Hiv-1 M184V Reverse Transcriptase-Dna Complex with (-)-Ftc-Tp also contains other interesting chemical elements:

Fluorine

(F)

1 atom

The binding sites of Magnesium atom in the Hiv-1 M184V Reverse Transcriptase-Dna Complex with (-)-Ftc-Tp (pdb code 6uir). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Hiv-1 M184V Reverse Transcriptase-Dna Complex with (-)-Ftc-Tp, PDB code: 6uir:

Magnesium binding site 1 out of 1 in the Hiv-1 M184V Reverse Transcriptase-Dna Complex with (-)-Ftc-Tp


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Hiv-1 M184V Reverse Transcriptase-Dna Complex with (-)-Ftc-Tp within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg604 b:28.1 occ:1.00 OD2 A:ASP110 2.2 35.0 1.0 O A:VAL111 2.2 24.5 1.0 OD2 A:ASP185 2.3 35.7 1.0 OAQ A:1RY601 2.6 51.9 1.0 O A:HOH726 2.8 31.1 1.0 OAH A:1RY601 2.8 34.1 1.0 OAG A:1RY601 2.9 49.9 1.0 PAZ A:1RY601 3.2 49.8 1.0 CG A:ASP110 3.3 31.8 1.0 C A:VAL111 3.4 20.3 1.0 CG A:ASP185 3.4 21.2 1.0 OAF A:1RY601 3.7 42.5 1.0 OD1 A:ASP110 3.8 41.4 1.0 PBB A:1RY601 3.8 58.4 1.0 OAR A:1RY601 3.9 34.6 1.0 PBA A:1RY601 4.1 46.8 1.0 N A:VAL111 4.1 19.7 1.0 CB A:ASP185 4.2 18.5 1.0 OD1 A:ASP185 4.3 19.7 1.0 OAE A:1RY601 4.3 48.4 1.0 N A:GLY112 4.3 16.0 1.0 CA A:GLY112 4.3 16.4 1.0 CA A:VAL111 4.3 18.3 1.0 CAL A:1RY601 4.3 32.6 1.0 CB A:ASP110 4.4 19.1 1.0 N A:ASP113 4.5 24.9 1.0 OAC A:1RY601 4.6 45.3 1.0 C A:GLY112 4.7 21.0 1.0 OAO A:1RY601 4.7 32.6 1.0 C A:ASP110 4.7 18.5 1.0 N A:ALA114 4.8 20.9 1.0 CB A:ALA114 4.9 18.2 1.0 CB A:VAL111 5.0 18.6 1.0

M.Hung, E.J.Tokarsky, L.Lagpacan, L.Zhang, Z.Suo, E.B.Lansdon. Elucidating Molecular Interactions of L-Nucleotides with Hiv-1 Reverse Transcriptase and Mechanism of M184V-Caused Drug Resistance Commun Biol V. 2 2019.
ISSN: ESSN 2399-3642
DOI: 10.1038/S42003-019-0706-X